CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Beta-galactosidase

Enzyme Information

3.2.1.23
Beta-galactosidase.
based on mapping to UniProt P00722
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D- galactosides.
-!- Some enzymes in this group hydrolyze alpha-L-arabinosides; some animal enzymes also hydrolyze beta-D-fucosides and beta-D-glucosides (cf. EC 3.2.1.108).

UniProtKB Entries (1)

P00722
BGAL_ECOLI
Escherichia coli K-12
Beta-galactosidase

PDB Structure

PDB 3IAQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Studies of Glu-416 variants of beta-galactosidase (E. coli) show that the active site Mg(2+) is not important for structure and indicate that the main role of Mg (2+) is to mediate optimization of active site chemistry
Lo, S., Dugdale, M.L., Jeerh, N., Ku, T., Roth, N.J., Huber, R.E.
Protein J.