CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.53
3',5'-cyclic-AMP phosphodiesterase.
based on mapping to UniProt P27815
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

P27815
PDE4A_HUMAN
Homo sapiens
CAMP-specific 3',5'-cyclic phosphodiesterase 4A

PDB Structure

PDB 3I8V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Cheng, R.K.Y., Crawley, L., Barker, J., Wood, M., Felicetti, B., Whittaker, M.
To be Published