CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.1080 |
Domain Context
CATH Clusters
| Superfamily | 1.20.120.1080 |
| Functional Family | Pre-mRNA-splicing factor ATP-dependent RNA helicase |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt Q14562
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
UniProtKB Entries (1)
| Q14562 |
DHX8_HUMAN
Homo sapiens
ATP-dependent RNA helicase DHX8
|
PDB Structure
| PDB | 3I4U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22
Biol.Chem.
|