CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-D-phosphohexomutase, C-terminal domain
Functional Family Phosphoglucosamine mutase

Enzyme Information

5.4.2.10
Phosphoglucosamine mutase.
based on mapping to UniProt Q5NII8
Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
-!- The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. -!- The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6- bisphosphate, which is an intermediate in the reaction, alpha-D- glucose 1,6-bisphosphate or ATP. -!- It can also catalyze the interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate, although at a much lower rate.

UniProtKB Entries (1)

Q5NII8
GLMM_FRATT
Francisella tularensis subsp. tularensis SCHU S4
Phosphoglucosamine mutase

PDB Structure

PDB 3I3W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a phosphoglucosamine mutase from Francisella tularensis
Brunzelle, J.S., Wawrzak, Z., Skarina, T., Onopriyenko, O., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To be Published