CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.86
Crotonyl-CoA reductase.
based on mapping to UniProt Q53865
Butanoyl-CoA + NADP(+) = (E)-but-2-enoyl-CoA + NADPH.
-!- Catalyzes the reaction in the reverse direction. -!- This enzyme from Streptomyces collinus is specific for (E)-but-2- enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.

UniProtKB Entries (1)

Q53865
CCR_STRCU
Streptomyces collinus
Crotonyl-CoA reductase

PDB Structure

PDB 3HZZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Streptomycs collinus crotonyl COA carboxylase/reductase
Scarsdale, J.N., Musayev, F.N., Hazzard, C., Florova, G., Reynolds, K., Wright, H.T.
To be Published