CATH Domain 3hwxJ01
|220.127.116.110||Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains|
|Functional Family||2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase|
based on mapping to UniProt P17109
Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl- cyclohex-3-ene-1-carboxylate + CO(2).
-!- Involved in the biosynthesis of vitamin K(2) (menaquinone). -!- In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. -!- It had previously been thought that the products of the reaction were (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate (SHCHC), pyruvate and CO(2) but it is now known that two separate enzymes are involved: this enzyme and EC 18.104.22.168. -!- Under basic conditions, the product can spontaneously lose pyruvate to form SHCHC. -!- Formerly EC 22.214.171.124 and EC 2.5.1.n1.
UniProtKB Entries (1)
Escherichia coli K-12
Structural and functional analysis of Vitamin K2 synthesis protein MenD.