CATH Classification

Domain Context

CATH Clusters

Superfamily Citrate Synthase, domain 1
Functional Family Citrate synthase

Enzyme Information

2.3.3.5
2-methylcitrate synthase.
based on mapping to UniProt I6Y9Q3
Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3- tricarboxylate + CoA.
-!- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. -!- The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1. -!- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate. -!- Formerly EC 4.1.3.31.
2.3.3.16
Citrate synthase (unknown stereospecificity).
based on mapping to UniProt I6Y9Q3
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C(2) of oxaloacetate has not been established (cf. EC 2.3.3.1 and EC 2.3.3.3).

UniProtKB Entries (1)

I6Y9Q3
PRPC_MYCTU
Mycobacterium tuberculosis H37Rv
2-methylcitrate synthase

PDB Structure

PDB 3HWK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Increasing the structural coverage of tuberculosis drug targets.
Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J.
Tuberculosis (Edinb)