CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00325
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00325
ADH1B_HUMAN
Homo sapiens
Alcohol dehydrogenase 1B

PDB Structure

PDB 3HUD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.
Hurley, T.D., Bosron, W.F., Hamilton, J.A., Amzel, L.M.
Proc.Natl.Acad.Sci.USA