CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.287.1400
Functional Family

Enzyme Information

2.3.3.13
2-isopropylmalate synthase.
based on mapping to UniProt P9WQB3
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.

UniProtKB Entries (1)

P9WQB3
LEU1_MYCTU
Mycobacterium tuberculosis H37Rv
2-isopropylmalate synthase

PDB Structure

PDB 3HPX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Huisman, F.H., Koon, N., Bulloch, E.M., Baker, H.M., Baker, E.N., Squire, C.J., Parker, E.J.
Biochemistry