CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P35956
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P35956
3.6.1.23
dUTP diphosphatase.
based on mapping to UniProt P35956
dUTP + H(2)O = dUMP + diphosphate.
3.1.13.2
Exoribonuclease H.
based on mapping to UniProt P35956
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
-!- This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13.
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P35956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P35956
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P35956
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P35956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (2)

O75475
PSIP1_HUMAN
Homo sapiens
PC4 and SFRS1-interacting protein
P35956
POL_VILVK
Visna/maedi virus EV1 KV1772
Gag-Pol polyprotein

PDB Structure

PDB 3HPH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for functional tetramerization of lentiviral integrase
Hare, S., Di Nunzio, F., Labeja, A., Wang, J., Engelman, A., Cherepanov, P.
Plos Pathog.