CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 3HLJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides
Baranauskiene, L., Hilvo, M., Matuliene, J., Golovenko, D., Manakova, E., Dudutiene, V., Michailoviene, V., Torresan, J., Jachno, J., Parkkila, S., Maresca, A., Supuran, C.T., Grazulis, S., Matulis, D.
J Enzyme Inhib Med Chem