CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family

Enzyme Information

2.9.1.2
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
based on mapping to UniProt Q9HD40
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate.
-!- In archaea and eukarya selenocysteine formation is achieved by a two- step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl- tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase. -!- Formerly EC 2.9.1.n1.

UniProtKB Entries (1)

Q9HD40
SPCS_HUMAN
Homo sapiens
O-phosphoseryl-tRNA(Sec) selenium transferase

PDB Structure

PDB 3HL2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
Palioura, S., Sherrer, R.L., Steitz, T.A., Soll, D., Simonovic, M.
Science