CATH Classification

CATH Clusters

Superfamily 2.20.25.410
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q980R2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

Q97ZJ9
RPOK_SULSO
Sulfolobus solfataricus P2
DNA-directed RNA polymerase subunit K
Q9UXD9
Q9UXD9_SULSF
Sulfolobus solfataricus
DNA-directed RNA polymerase subunit F

PDB Structure

PDB 3HKZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The X-ray crystal structure of RNA polymerase from Archaea.
Hirata, A., Klein, B.J., Murakami, K.S.
Nature