CATH Classification

Domain Context

CATH Clusters

Superfamily Chorismate mutase
Functional Family

Enzyme Information

5.4.99.5
Chorismate mutase.
based on mapping to UniProt Q51507
Chorismate = prephenate.
4.2.99.21
Isochorismate lyase.
based on mapping to UniProt Q51507
Isochorismate = salicylate + pyruvate.
-!- This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin.

UniProtKB Entries (1)

Q51507
PCHB_PSEAE
Pseudomonas aeruginosa PAO1
Isochorismate pyruvate lyase

PDB Structure

PDB 3HGX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme.
Luo, Q., Olucha, J., Lamb, A.L.
Biochemistry