CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.112
Anthocyanidin reductase ((2S)-flavan-3-ol-forming).
based on mapping to UniProt Q5FB34
(1) A (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH. (2) A (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH.
-!- The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. -!- It catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. -!- The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively. -!- Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. -!- Cf. EC 1.3.1.77.

UniProtKB Entries (1)

Q5FB34
ANRCS_VITVI
Vitis vinifera
Anthocyanidin reductase ((2S)-flavan-3-ol-forming)

PDB Structure

PDB 3HFS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera.
Gargouri, M., Manigand, C., Mauge, C., Granier, T., Langlois d'Estaintot, B., Cala, O., Pianet, I., Bathany, K., Chaudiere, J., Gallois, B.
Acta Crystallogr.,Sect.D