CATH Domain 3hdhB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	3-hydroxybutyryl-CoA dehydrogenase FadB2

Enzyme Information

1.1.1.35

3-hydroxyacyl-CoA dehydrogenase.

based on mapping to UniProt P00348

(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.

-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

P00348

HCDH_PIG

Sus scrofa

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

PDB Structure

PDB	3HDH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pig heart short chain L-3-hydroxyacyl-CoA dehydrogenase revisited: sequence analysis and crystal structure determination. Barycki, J.J., O'Brien, L.K., Birktoft, J.J., Strauss, A.W., Banaszak, L.J. Protein Sci.