CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Phenylethanolamine N-methyltransferase

Enzyme Information

2.1.1.28
Phenylethanolamine N-methyltransferase.
based on mapping to UniProt P11086
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
-!- Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

UniProtKB Entries (1)

P11086
PNMT_HUMAN
Homo sapiens
Phenylethanolamine N-methyltransferase

PDB Structure

PDB 3HCB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Drinkwater, N., Gee, C.L., Puri, M., Criscione, K.R., McLeish, M.J., Grunewald, G.L., Martin, J.L.
Biochem.J.