CATH Classification

Domain Context

CATH Clusters

Superfamily Serralysin-like metalloprotease, C-terminal
Functional Family

Enzyme Information

3.4.24.40
Serralysin.
based on mapping to UniProt P16317
Preferential cleavage of bonds with hydrophobic residues in P1'.
-!- An extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi. -!- There is broad specificity in cleavage of the insulin B chain, with some species variations. -!- The pH optimum for digesting various proteins is about 9-10. -!- Belongs to peptidase family M10A. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

P16317
PRTC_DICCH
Dickeya chrysanthemi
Serralysin C

PDB Structure

PDB 3HBV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
Oberholzer, A.E., Bumann, M., Hege, T., Russo, S., Baumann, U.
Biol.Chem.