CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Blood coagulation factor II

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P09945
HIRV2_HIRME
Hirudo medicinalis
Hirudin variant-2

PDB Structure

PDB 3HAT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active-site mimetic inhibition of thrombin.
Mathews, I.I., Tulinsky, A.
Acta Crystallogr.,Sect.D