CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt O14556
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

O14556
G3PT_HUMAN
Homo sapiens
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

PDB Structure

PDB 3H9E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.
Chaikuad, A., Shafqat, N., Al-Mokhtar, R., Cameron, G., Clarke, A.R., Brady, R.L., Oppermann, U., Frayne, J., Yue, W.W.
Biochem.J.