CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Anthraniloyl-CoA anthraniloyltransferase

Enzyme Information

2.3.1.262
Anthraniloyl-CoA anthraniloyltransferase.
based on mapping to UniProt P20582
Anthraniloyl-CoA + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CoA + CO(2).
-!- The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. -!- The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone. -!- However, when EC 3.1.2.32 is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.

UniProtKB Entries (1)

P20582
PQSD_PSEAE
Pseudomonas aeruginosa PAO1
Anthraniloyl-CoA anthraniloyltransferase

PDB Structure

PDB 3H77
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate.
Bera, A.K., Atanasova, V., Robinson, H., Eisenstein, E., Coleman, J.P., Pesci, E.C., Parsons, J.F.
Biochemistry