CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family Pyrimidine-nucleoside phosphorylase

Enzyme Information

2.4.2.2
Pyrimidine-nucleoside phosphorylase.
based on mapping to UniProt Q5HE64
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

Q5HE64
PDP_STAAC
Staphylococcus aureus subsp. aureus COL
Pyrimidine-nucleoside phosphorylase

PDB Structure

PDB 3H5Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a putative pyrimidine-nucleoside phosphorylase from Staphylococcus aureus
Shumilin, I.A., Zimmerman, M., Cymborowski, M., Skarina, T., Onopriyenko, O., Anderson, W.F., Savchenko, A., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)
TO BE PUBLISHED