CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Alpha-galactosidase

Enzyme Information

3.2.1.49
Alpha-N-acetylgalactosaminidase.
based on mapping to UniProt P17050
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.
-!- The human lysosomal enzyme is involved in the degradation of blood type A epitope.

UniProtKB Entries (1)

P17050
NAGAB_HUMAN
Homo sapiens
Alpha-N-acetylgalactosaminidase

PDB Structure

PDB 3H54
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases
Clark, N.E., Garman, S.C.
J.Mol.Biol.