CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Selenocysteine lyase

Enzyme Information

4.4.1.16
Selenocysteine lyase.
based on mapping to UniProt Q96I15
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.
-!- Dithiothreitol or 2-mercaptoethanol can act as the reducing agent in the reaction. -!- The enzyme from animals does not act on cysteine, serine or chloroalanine, while the enzyme from bacteria shows activity with cysteine (cf. EC 2.8.1.7).

UniProtKB Entries (1)

Q96I15
SCLY_HUMAN
Homo sapiens
Selenocysteine lyase

PDB Structure

PDB 3GZD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.
Collins, R., Johansson, A.L., Karlberg, T., Markova, N., van den Berg, S., Olesen, K., Hammarstrom, M., Flores, A., Schuler, H., Schiavone, L.H., Brzezinski, P., Arner, E.S., Hogbom, M.
Plos One