CATH Domain 3gvkA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.30	Elongation Factor Tu (Ef-tu); domain 3
	2.40.30.20

Domain Context

CATH Clusters

Superfamily	2.40.30.20
Functional Family

Enzyme Information

3.2.1.129

Endo-alpha-sialidase.

based on mapping to UniProt Q04830

Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids.

-!- Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetyl-substituted substrates. -!- An exo-alpha-sialidase activity is listed as EC 3.2.1.18. -!- See also 4.2.2.15.

UniProtKB Entries (1)

Q04830

FIBER_BPK1F

Enterobacteria phage K1F

Tail spike protein

PDB Structure

PDB	3GVK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF. Schulz, E.C., Schwarzer, D., Frank, M., Stummeyer, K., Muhlenhoff, M., Dickmanns, A., Gerardy-Schahn, R., Ficner, R. J.Mol.Biol.