CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.465.10
Functional Family

Enzyme Information

1.21.3.3
Reticuline oxidase.
based on mapping to UniProt P30986
(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).
-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.

UniProtKB Entries (1)

P30986
RETO_ESCCA
Eschscholzia californica
Reticuline oxidase

PDB Structure

PDB 3GSY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine.
Winkler, A., Puhl, M., Weber, H., Kutchan, T.M., Gruber, K., Macheroux, P.
Phytochemistry