CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.390.30
Functional Family Glutathione reductase

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P00390
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P00390
GSHR_HUMAN
Homo sapiens
Glutathione reductase, mitochondrial

PDB Structure

PDB 3GRT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Biochemistry