CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P11362
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P11362
FGFR1_HUMAN
Homo sapiens
Fibroblast growth factor receptor 1

PDB Structure

PDB 3GQL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J.
Cell(Cambridge,Mass.)