CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P50172
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P50172
DHI1_MOUSE
Mus musculus
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 3GMD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I.
Valeur, E., Christmann-Franck, S., Lepifre, F., Carniato, D., Cravo, D., Charon, C., Bozec, S., Musil, D., Hillertz, P., Doare, L., Schmidlin, F., Lecomte, M., Schultz, M., Roche, D.
Bioorg.Med.Chem.Lett.