CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 3GI2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Gangjee, A., Li, W., Kisliuk, R.L., Cody, V., Pace, J., Piraino, J., Makin, J.
J.Med.Chem.