CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P00491
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P00491
PNPH_HUMAN
Homo sapiens
Purine nucleoside phosphorylase

PDB Structure

PDB 3GB9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.
Afshar, S., Sawaya, M.R., Morrison, S.L.
Protein Sci.