CATH Classification

Domain Context

CATH Clusters

Superfamily RIG-I-like receptor, C-terminal regulatory domain
Functional Family Interferon-induced with helicase C domain 1

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt Q9BYX4
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9BYX4
IFIH1_HUMAN
Homo sapiens
Interferon-induced helicase C domain-containing protein 1

PDB Structure

PDB 3GA3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the C-terminal domain of human MDA5
Li, P., Li, X., Lu, C.
To be Published