CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.1940
Functional Family tRNA(cytosine(8)) deaminase

Enzyme Information

3.5.4.35
tRNA(cytosine(8)) deaminase.
based on mapping to UniProt Q8TWU6
Cytosine(8) in tRNA + H(2)O = uracil(8) in tRNA + NH(3).
-!- The enzyme from Methanopyrus kandleri specifically catalyzes the deamimation of cytosine at poition 8 of tRNA in 30 different tRNAs. -!- This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs.

UniProtKB Entries (1)

Q8TWU6
CDAT8_METKA
Methanopyrus kandleri AV19
TRNA(cytosine(8)) deaminase

PDB Structure

PDB 3G8Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A cytidine deaminase edits C to U in transfer RNAs in Archaea
Randau, L., Stanley, B.J., Kohlway, A., Mechta, S., Xiong, Y., Soll, D.
Science