CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Choline kinase alpha

Enzyme Information

2.7.1.82
Ethanolamine kinase.
based on mapping to UniProt P35790
ATP + ethanolamine = ADP + O-phosphoethanolamine.
2.7.1.32
Choline kinase.
based on mapping to UniProt P35790
ATP + choline = ADP + phosphocholine.
-!- Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.

UniProtKB Entries (1)

P35790
CHKA_HUMAN
Homo sapiens
Choline kinase alpha

PDB Structure

PDB 3G15
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
Hong, B.S., Allali-Hassani, A., Tempel, W., Finerty, P.J., Mackenzie, F., Dimov, S., Vedadi, M., Park, H.W.
J.Biol.Chem.