CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family MAP kinase-activated protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49137
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49137
MAPK2_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 2

PDB Structure

PDB 3FYJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Anderson, D.R., Meyers, M.J., Kurumbail, R.G., Caspers, N., Poda, G.I., Long, S.A., Pierce, B.S., Mahoney, M.W., Mourey, R.J., Parikh, M.D.
Bioorg.Med.Chem.Lett.