CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family 6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P00350
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P00350
6PGD_ECOLI
Escherichia coli K-12
6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB 3FWN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism
Chen, Y.-Y., Ko, T.-P., Chen, W.-H., Lo, L.-P., Lin, C.-H., Wang, A.H.-J.
J.Struct.Biol.