CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Ketol-acid reductoisomerase

Enzyme Information

1.1.1.86
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt Q65XK0
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

Q65XK0
ILV5_ORYSJ
Oryza sativa Japonica Group
Ketol-acid reductoisomerase, chloroplastic

PDB Structure

PDB 3FR8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures
Leung, E.W., Guddat, L.W.
J.Mol.Biol.