CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase II, domain 5
Functional Family DNA gyrase subunit A

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P72525
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P72525
PARC_STRPN
Streptococcus pneumoniae TIGR4
DNA topoisomerase 4 subunit A

PDB Structure

PDB 3FOE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Laponogov, I., Sohi, M.K., Veselkov, D.A., Pan, X.-S., Sawhney, R., Thompson, A.W., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Nat.Struct.Mol.Biol.