CATH Domain 3fl8B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Dihydrofolate reductase

Enzyme Information

UniProtKB Entries (1)

Q81R22_BACAN

Bacillus anthracis

Dihydrofolate reductase

PDB Structure

PDB	3FL8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Bourne, C.R., Bunce, R.A., Bourne, P.C., Berlin, K.D., Barrow, E.W., Barrow, W.W. Antimicrob.Agents Chemother.