CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.1070.20
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P38902
RPB11_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB11

PDB Structure

PDB 3FKI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data
Meyer, P.A., Ye, P., Suh, M.H., Zhang, M., Fu, J.
J.Biol.Chem.