CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family

Enzyme Information

1.11.1.16
Versatile peroxidase.
based on mapping to UniProt O94753
(1) 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H(2)O(2) = 4-hydroxy-3-methoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H(2)O. (2) 2 manganese(II) + 2 H(+) + H(2)O(2) = 2 manganese(III) + 2 H(2)O.
-!- This ligninolytic peroxidase combines the substrate-specificity characteristics of the two other ligninolytic peroxidases, EC 1.11.1.13 and EC 1.11.1.14. -!- Unlike these two enzymes, it is also able to oxidize phenols, hydroquinones and both low- and high-redox-potential dyes, due to a hybrid molecular architecture that involves multiple binding sites for substrates.

UniProtKB Entries (1)

O94753
VPL2_PLEER
Pleurotus eryngii
Versatile peroxidase VPL2

PDB Structure

PDB 3FKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Site-directed Mutagenesis Study of Versatile Peroxidase Oxidizing both Mn(II) and Aromatic Substrates
Piontek, K., Choinowski, T., Perez-Boada, M., Ruiz-Duenas, F.J., Martinez, M.J., Plattner, D.A., Martinez, A.T.
To be Published