CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1240 | Zincin-like |
|
3.90.1240.10 | Metalloproteases ("zincins"), catalytic domain like |
Domain Context
CATH Clusters
| Superfamily | Metalloproteases ("zincins"), catalytic domain like |
| Functional Family | Botulinum neurotoxin type B |
Enzyme Information
| 3.4.24.69 |
Bontoxilysin.
based on mapping to UniProt A7GBG3
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.
|
UniProtKB Entries (2)
| P63027 |
VAMP2_HUMAN
Homo sapiens
Vesicle-associated membrane protein 2
|
| A7GBG3 |
BXF_CLOBL
Clostridium botulinum F str. Langeland
Botulinum neurotoxin type F
|
PDB Structure
| PDB | 3FII |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.
Nat.Struct.Mol.Biol.
|