CATH Classification

Domain Context

CATH Clusters

Superfamily Hypothetical protein; domain 2
Functional Family

Enzyme Information

4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt Q58134
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
3.2.2.-
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt Q58134

UniProtKB Entries (1)

Q58134
OGG1_METJA
Methanocaldococcus jannaschii DSM 2661
N-glycosylase/DNA lyase

PDB Structure

PDB 3FHF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.
Faucher, F., Duclos, S., Bandaru, V., Wallace, S.S., Doublie, S.
Structure