CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P26918
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P26918
BLAB_AERHY
Aeromonas hydrophila
Metallo-beta-lactamase type 2

PDB Structure

PDB 3FAI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Bebrone, C., Delbruck, H., Kupper, M.B., Schlomer, P., Willmann, C., Frere, J.-M., Fischer, R., Galleni, M., Hoffmann, K.M.V.
Antimicrob.Agents Chemother.