CATH Classification

Domain Context

CATH Clusters

Superfamily Urate Oxidase;
Functional Family Uricase

Enzyme Information

1.7.3.3
Factor independent urate hydroxylase.
based on mapping to UniProt Q00511
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2).
-!- Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. -!- The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO(2), although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step. -!- The enzyme is different from EC 1.14.13.113.

UniProtKB Entries (1)

Q00511
URIC_ASPFL
Aspergillus flavus
Uricase

PDB Structure

PDB 3F2M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-function perturbation and dissociation of tetrameric urate oxidase by high hydrostatic pressure.
Girard, E., Marchal, S., Perez, J., Finet, S., Kahn, R., Fourme, R., Marassio, G., Dhaussy, A.C., Prange, T., Giffard, M., Dulin, F., Bonnete, F., Lange, R., Abraini, J.H., Mezouar, M., Colloc'h, N.
Biophys.J.