CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q14318
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q14318
FKBP8_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP8

PDB Structure

PDB 3EY6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.
Maestre-Martinez, M., Haupt, K., Edlich, F., Neumann, P., Parthier, C., Stubbs, M.T., Fischer, G., Luecke, C.
J.Mol.Recognit.