CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P28845
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P28845
DHI1_HUMAN
Homo sapiens
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 3EY4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
Christopher, F., Bartberger, M.D., Bercot, E.A., Chen, M., Cupples, R., Emery, M., Fretland, J., Guram, A., Hale, C., Han, N.H., Hickman, D., Hungate, R.W., Hayashi, M., Komorowski, R., Liu, Q.Y., Matsumoto, G., Jean, D.J.St., Ursu, S., Voniant, M., Xu, G.F., Ye, Q.P., Yuan, C., Zhang, J.D., Zhang, X.P., Tu, H., Wang, M.H.
To be Published