CATH Classification

Domain Context

CATH Clusters

Superfamily Poxvirus poly(A) polymerase, nucleotidyltransferase domain
Functional Family

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P23371
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P07617
MCE_VACCW
Vaccinia virus WR
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

PDB Structure

PDB 3ER9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase
Li, C., Li, H., Zhou, S., Sun, E., Yoshizawa, J., Poulos, T.L., Gershon, P.D.
Structure