CATH Classification

Domain Context

CATH Clusters

Superfamily Prolyl oligopeptidase, N-terminal domain
Functional Family Prolyl endopeptidase

Enzyme Information

3.4.21.26
Prolyl oligopeptidase.
based on mapping to UniProt P23687
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P23687
PPCE_PIG
Sus scrofa
Prolyl endopeptidase

PDB Structure

PDB 3EQ8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
Kanai, K., Aranyi, P., Bocskei, Z., Ferenczy, G., Harmat, V., Simon, K., Batori, S., Naray-Szabo, G., Hermecz, I.
J.Med.Chem.