CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, Y-family, little finger domain
Functional Family Polymerase (DNA directed) iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 3EPI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
Pence, M.G., Blans, P., Zink, C.N., Hollis, T., Fishbein, J.C., Perrino, F.W.
J.Biol.Chem.